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miRNAs in non-alcoholic fatty liver disease
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 389-396 doi: 10.1007/s11684-016-0468-5
Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver cirrhosis and hepatocellular carcinoma and is a considerable threat to public health. miRNAs are important post-transcriptional regulators of gene expression, and the dysregulation of miRNAs is involved in various biological processes in the liver, including lipid homeostasis, inflammation, apoptosis, and cell proliferation. Recently, a number of studies have described the association between miRNAs and NAFLD progression and have shown that circulating miRNAs reflect histological changes in the liver. Therefore, circulating miRNAs have potential use for the evaluation of NAFLD severity. In this review, we discuss the involvement of miRNAs in NAFLD pathogenesis and the key role of miRNAs in the screening, diagnosis, and staging of NAFLD.
关键词: nonalcoholic fatty liver disease nonalcoholic steatohepatitis hepatocellular carcinoma miRNA
《医学前沿(英文)》 2022年 第16卷 第5期 页码 667-685 doi: 10.1007/s11684-022-0960-z
关键词: Akkermansia muciniphila NAFLD NASH steatosis inflammation
Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,
《工程(英文)》 doi: 10.1016/j.eng.2022.10.010
关键词: Pien Tze Huang Non-alcoholic steatohepatitis Gut barrier function Gut microbiota
Pathological study of 130 cases of nonalcoholic fatty liver disease based on NASH-CRN system
ZHOU Guangde, ZHAO Jingmin, DING Xiaohui, PAN Deng, SUN Yanling, YANG Jianfa, ZHAO Yulai
《医学前沿(英文)》 2007年 第1卷 第4期 页码 413-417 doi: 10.1007/s11684-007-0081-8
Molecular mechanisms of fatty liver in obesity
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《医学前沿(英文)》 2015年 第9卷 第3期 页码 275-287 doi: 10.1007/s11684-015-0410-2
Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver disorders ranging from simple steatosis to advanced pathologies, including nonalcoholic steatohepatitis and cirrhosis. NAFLD significantly contributes to morbidity and mortality in developed societies. Insulin resistance associated with central obesity is the major cause of hepatic steatosis, which is characterized by excessive accumulation of triglyceride-rich lipid droplets in the liver. Accumulating evidence supports that dysregulation of adipose lipolysis and liver de novo lipogenesis (DNL) plays a key role in driving hepatic steatosis. In this work, we reviewed the molecular mechanisms responsible for enhanced adipose lipolysis and increased hepatic DNL that lead to hepatic lipid accumulation in the context of obesity. Delineation of these mechanisms holds promise for developing novel avenues against NAFLD.
关键词: nonalcoholic fatty liver disease insulin resistance obesity
《医学前沿(英文)》 2021年 第15卷 第3期 页码 460-471 doi: 10.1007/s11684-021-0861-6
关键词: low-carbohydrate diet obesity nonalcoholic fatty liver disease continuous glucose monitoring mean sensor glucose
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《医学前沿(英文)》 2018年 第12卷 第3期 页码 249-261 doi: 10.1007/s11684-018-0622-3
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases. In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma. Controversial results from previous studies are discussed, and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver diseases, which might be caused by changes in natural killer T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer T cells and CD1d-expressing cells or bystander cells.
关键词: natural killer T cells hepatitis B virus and hepatitis C virus infection autoimmune liver diseases alcoholic liver disease nonalcoholic fatty liver disease hepatocellular carcinoma
吕桂帅, 程宁涛, 王红阳
《工程(英文)》 2017年 第3卷 第1期 页码 110-114 doi: 10.1016/J.ENG.2017.01.017
一个多世纪以前,科学家们就首次发现了肿瘤区域中细菌的存在。但是,微生物在肿瘤发生中的作用近年来才被认识到。近几十年来,与肠道菌群失调相关的疾病代表了全世界最严重的一些公共卫生问题。大量的流行病学研究表明,肠道菌群与某些常见肿瘤密切相关。然而,肠道菌群与肿瘤相关联的具体分子机制仍不明确。研究表明,肠道菌群的改变有助于确定肝癌、酒精相关肝病、非酒精性脂肪肝和肝硬化的发生和发展。鉴于益生菌是一种可通过调节免疫系统促进人类健康的药物,其可能会为肝细胞癌(HCC) 和非酒精性脂肪肝的治疗提供新方向。本文总结了肠道菌群在肿瘤及肝病中的研究进展,综述了肠道菌群与肿瘤和肝病之间的关系。此外,考虑到细菌内稳态的重要性,我们也对益生菌进行了概述,旨在为相关疾病的治疗提供指导。
标题 作者 时间 类型 操作
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge
期刊论文
Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites
Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,
期刊论文
Pathological study of 130 cases of nonalcoholic fatty liver disease based on NASH-CRN system
ZHOU Guangde, ZHAO Jingmin, DING Xiaohui, PAN Deng, SUN Yanling, YANG Jianfa, ZHAO Yulai
期刊论文
Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial
期刊论文